Fully human monoclonal antibody directed to proteolytic cleavage site in severe acute respiratory syndrome (SARS) coronavirus S protein neutralizes the virus in a rhesus macaque SARS model.

Fully human monoclonal antibody directed to proteolytic cleavage site in severe acute respiratory syndrome (SARS) coronavirus S protein neutralizes the virus in a rhesus macaque SARS model.

Source :

• The Journal of infectious diseases [ 1537-6613 ] ; 2011.

Descripteurs français

• KwdFr :
  • Animal génétiquement modifié, Animaux, Anticorps antiviraux (immunologie), Anticorps antiviraux (métabolisme), Anticorps monoclonaux (immunologie), Anticorps monoclonaux (métabolisme), Anticorps monoclonaux (pharmacologie), Anticorps neutralisants (immunologie), Anticorps neutralisants (métabolisme), Cellules géantes (), Domaine catalytique, Fusion cellulaire, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (génétique), Glycoprotéines membranaires (immunologie), Humains, Immunohistochimie, Macaca mulatta, Modèles animaux de maladie humaine, Peptidyl-Dipeptidase A, Poumon (anatomopathologie), Poumon (virologie), Protéines de l'enveloppe virale (génétique), Protéines de l'enveloppe virale (immunologie), Protéines recombinantes (génétique), Protéines recombinantes (immunologie), Protéines recombinantes (pharmacologie), RT-PCR, Souris, Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (virologie), Technique de Western, Virus du SRAS (immunologie).
• MESH :
  • anatomopathologie : Poumon.
  • génétique : Glycoprotéines membranaires, Protéines de l'enveloppe virale, Protéines recombinantes.
  • immunologie : Anticorps antiviraux, Anticorps monoclonaux, Anticorps neutralisants, Glycoprotéines membranaires, Protéines de l'enveloppe virale, Protéines recombinantes, Syndrome respiratoire aigu sévère, Virus du SRAS.
  • métabolisme : Anticorps antiviraux, Anticorps monoclonaux, Anticorps neutralisants.
  • pharmacologie : Anticorps monoclonaux, Protéines recombinantes.
  • virologie : Poumon, Syndrome respiratoire aigu sévère.
  • Animal génétiquement modifié, Animaux, Cellules géantes, Domaine catalytique, Fusion cellulaire, Glycoprotéine de spicule des coronavirus, Humains, Immunohistochimie, Macaca mulatta, Modèles animaux de maladie humaine, Peptidyl-Dipeptidase A, RT-PCR, Souris, Syndrome respiratoire aigu sévère, Technique de Western.

English descriptors

• KwdEn :
  • Animals, Animals, Genetically Modified, Antibodies, Monoclonal (immunology), Antibodies, Monoclonal (metabolism), Antibodies, Monoclonal (pharmacology), Antibodies, Neutralizing (immunology), Antibodies, Neutralizing (metabolism), Antibodies, Viral (immunology), Antibodies, Viral (metabolism), Blotting, Western, Catalytic Domain, Cell Fusion, Disease Models, Animal, Giant Cells (drug effects), Humans, Immunohistochemistry, Lung (pathology), Lung (virology), Macaca mulatta, Membrane Glycoproteins (genetics), Membrane Glycoproteins (immunology), Mice, Peptidyl-Dipeptidase A, Recombinant Proteins (genetics), Recombinant Proteins (immunology), Recombinant Proteins (pharmacology), Reverse Transcriptase Polymerase Chain Reaction, SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (therapy), Severe Acute Respiratory Syndrome (virology), Spike Glycoprotein, Coronavirus, Viral Envelope Proteins (genetics), Viral Envelope Proteins (immunology).
• MESH :
  • chemical , genetics : Membrane Glycoproteins, Recombinant Proteins, Viral Envelope Proteins.
  • chemical , immunology : Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Membrane Glycoproteins, Recombinant Proteins, Viral Envelope Proteins.
  • chemical , metabolism : Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral.
  • chemical , pharmacology : Antibodies, Monoclonal, Recombinant Proteins.
  • drug effects : Giant Cells.
  • immunology : SARS Virus, Severe Acute Respiratory Syndrome.
  • pathology : Lung.
  • therapy : Severe Acute Respiratory Syndrome.
  • virology : Lung, Severe Acute Respiratory Syndrome.
  • Animals, Animals, Genetically Modified, Blotting, Western, Catalytic Domain, Cell Fusion, Disease Models, Animal, Humans, Immunohistochemistry, Macaca mulatta, Mice, Peptidyl-Dipeptidase A, Reverse Transcriptase Polymerase Chain Reaction, Spike Glycoprotein, Coronavirus.

Abstract

Affiliations:

• Japon
• Région de Kantō
• Tokyo

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